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Home › Robotic Medicine › Protocol library › RMP-MSK-001

CONCEPTUAL · DRAFT v0.2 · NOT FOR CLINICAL USE. An educational thought experiment about how a care robot could follow an auditable protocol. It is not a medical procedure, has not been validated, and must not be used to care for anyone. Thresholds marked <set by …> are deliberately left for clinical leads and validation to set. Disclaimer
Robotic Medicine · Protocol library

RMP-MSK-001 Major trauma: bring trauma kit, video, assist crew (the robot does not lead)

AI-assisted Reviewed (AI-assisted) AI-assisted clinical and source review by the Medical Research Assistant, Oct 21, 2026 (batch 6 review, 26 required corrections and 17 optional suggestions); all required corrections, and the low-risk suggestions, are applied in this version (see Corrections). No named human clinician has reviewed it. Not for clinical use.

Fixed rules (same in every protocol)

1 · Identity and scope

After a serious injury (a crush, a high-energy impact, a fall during surface operations, heavy bleeding, or an injury with reduced responsiveness), the robot sends an URGENT alert at once, brings the sealed trauma kit and other emergency kits on command, clears space and restrains loose items, records the CMO's stated assessment in the <C>ABCDE order as a clock-time timeline, and streams video when the link allows. The CMO and crew give all trauma care. The robot never touches the injured crewmember.

Why this protocol was chosen. Trauma is a planning concern for exploration missions, where help is far away; NASA's in-flight medical conditions evidence report describes rapid ultrasound to look for internal bleeding after injury, used by minimally trained crew. On Earth, NICE guideline NG39 orders the first assessment as <C>ABCDE: catastrophic bleeding first, then airway with in-line spinal immobilisation (keeping the neck in line), breathing, circulation, disability (neurological state) and exposure, recording whether the patient is improving or getting worse. In weightlessness, blood and loose objects float and the patient and rescuer must be restrained. A helper that alerts, fetches and keeps the scene clear frees the crew's hands. Open question for review: the onboard method for restraining patient and rescuer for bleeding control in weightlessness, and whether the robot should record a timer for a tourniquet the crew apply (clock time only, never an endpoint).

Autonomy: Max rung raised from 1 to 2 for supervised fetching of the trauma kit, clearing space and video. The robot never applies pressure, a tourniquet, a binder or a collar, never moves the injured crewmember, and never leads the response.

Covers

  • Serious injury in flight or on a planetary surface, including heavy bleeding, crush or impact
  • Support while the CMO runs the onboard trauma checklist
  • Routing to RMP-NEURO-001 (head injury), RMP-MSK-002 (limb injury), RMP-SKIN-001 (wounds; not used for an open fracture unless the flight surgeon directs), RMP-SKIN-002 (burns), RMP-CARD-001 (no signs of life)

Locked out (never done by the robot under this protocol)

  • Diagnosis or naming a cause
  • Any medicine, fluid or oxygen advice; starting, stopping or adjusting oxygen
  • Touching the crewmember
  • Handing over any medicine outside RMP-PHARM-001, or after a MISMATCH or CANNOT VERIFY (the item stays quarantined; only the CMO can ask for it, through the RMP-PHARM-001 logged two-step override)
  • Applying pressure, a dressing, a tourniquet, a pelvic binder, a collar or a splint
  • Moving, turning or restraining the injured crewmember
  • Saying bleeding is controlled or that the spine is uninjured
  • Holding an ultrasound probe (see RMP-RENAL-001 for the imaging pattern; trauma imaging is crew-led)
  • Touching, moving or commenting on an object stuck in a wound; the CMO follows the onboard checklist

Related: RMP-NEURO-001 · RMP-MSK-002 · RMP-MSK-004 · RMP-SKIN-001 · RMP-SKIN-002 · RMP-CARD-001 · RMP-RESP-001 · RMP-PHARM-001

2 · Roles

Medical authority
Flight surgeon (ground). Holds medical authority for every run.
Onboard lead
Crew medical officer (CMO), acting under delegated care; uses the pre-approved onboard checklist when there is no link.
Others
  • Second trained CMO: receives every alert and takes over if the CMO is the patient
  • Vehicle commander: leads any cabin emergency procedure
  • Other crew: help as the CMO or commander directs
Commercial flights
On commercial flights, 'flight surgeon' and 'CMO' mean the operator's designated medical authority and trained onboard responder. If no trained responder is aboard, this protocol is not used. (NASA-STD-3001 requires two CMOs per vehicle for NASA programs [V1 3006]; FAA rules set no medical standards for spaceflight participants.) [11]

Robot may

  • Send an URGENT alert at once
  • Bring the sealed trauma kit and emergency kits on command
  • Clear and restrain loose items and floating debris away from the scene
  • Record the CMO's stated <C>ABCDE findings and actions with clock times
  • Stream video when the link allows
  • Reconcile kits afterwards through RMP-PHARM-001 as an inventory record only

Robot may not

  • Touch, move or restrain the injured crewmember
  • Apply any dressing, pressure, tourniquet, binder, collar or splint
  • Judge bleeding, breathing or spinal injury
  • Start without a human command

3 · Preconditions and consent

Consent
Emergency care; recording by the CMO's agreement when the crewmember cannot speak.
Emergency consent
If the crewmember cannot agree, the robot proceeds on the CMO's or commander's command.
Withdrawal
The crewmember or CMO can stop video; the alert and record stand.

4 · Required sensor inputs

IDInputSourceRequiredIf missing
IN-1Injury as stated (what happened, where it hurts, heavy bleeding)VoiceYesLog "no response"; keep the URGENT alert.
IN-2CMO's stated findings in <C>ABCDE order and each action with its clock time (including any tourniquet time the crew state)CMOOptionalLog "not stated".
IN-3Responsiveness as stated by the CMOCMOOptionalLog "not stated"; treat as URGENT.
IN-4Link status and delayCommunications systemYesTreat as link down.

5–6 · Steps and decision points

Each step names who acts. Decision points sit after the step they follow and say who decides: Robot Crew Ground. Any stop rule in section 7 can interrupt any step.

  1. S1RobotRung 2

    On a crewmember's, the CMO's or the commander's word, send an URGENT "major trauma" alert to the flight surgeon and the CMO at once. Every URGENT alert goes to the CMO and the flight surgeon at the same time (queued for the flight surgeon if the link is down). If the CMO is the patient, is busy treating, or does not answer, the alert goes to the second trained CMO, or the crewmember named before flight [V1 3006]. An URGENT alert that is not acknowledged within <set by validation> seconds is repeated and sent to the next named crewmember.

    Done when: Alert acknowledged, or escalated.

    V2 10174V1 6003V1 3006

  2. S2RobotRung 2

    On the CMO's or commander's command, bring the sealed trauma kit and emergency kit, with eye protection and absorbent containment supplies, to the CMO and restrain them within reach. This is an emergency fetch on a human command (CMO or commander): no barcode check runs before hand-over and nothing waits for one. The robot reads the kit's own label and seal status only if that adds no delay, says "EMERGENCY FETCH – NOT VERIFIED (CMO or commander command)", and "seal not intact" if so, and hands the kit over anyway. The fetch is logged as an override: time, who asked, the reason as stated, kit ID and seal status. It never says "verified".

    Done when: Kits within reach, or skipped; override logged.

    Limit: <set by validation>

    V2 7046

  3. S3Crew

    The CMO leads trauma care under the onboard checklist (Earth context: NICE NG39 <C>ABCDE). Crew restrain patient and rescuer as the checklist directs. The robot stays clear.

    Done when: Human-led care; robot logs what is stated.

    V1 3004

    D1DecisionCrew decides

    Does the crewmember show no signs of life (unresponsive, not breathing normally)?

    • Yes → Start RMP-CARD-001 at once; this record continues as context.
    • No → Continue trauma care.
  4. S4RobotRung 2

    Clear and restrain loose items away from the scene (never near the patient's body), hold clear of the CMO, stream video when the link allows unless the CMO stops it, and log each stated finding and action on a clock-time timeline.

    Done when: Scene clear; timeline logged.

    V1 6003

    D2DecisionRobot decides

    Checked after every answer and at any point in the run (even mid-question or mid-step): does any answer, reading or observation meet a red flag?

    • Yes → Stop the current question or step at once and apply the action listed for each matching red flag (URGENT alert, flag, or stop), with the answer or reading itself, never a cause. Every URGENT alert goes to the CMO and the flight surgeon at the same time (queued for the flight surgeon if the link is down). If the CMO is the patient, is busy treating, or does not answer, the alert goes to the second trained CMO, or the crewmember named before flight [V1 3006]. An URGENT alert that is not acknowledged within <set by validation> seconds is repeated and sent to the next named crewmember.
    • No → Continue.
    D3DecisionRobot decides

    Did the CMO answer when asked for a stated finding or time?

    • Yes → Continue.
    • Declined explicitly (the crewmember says no to a question) → Log "declined" for that question only; the alert already sent stands.
    • No response, or the answer does not make sense → URGENT: log "no response" (never "declined"); the CMO, or the second trained CMO if the CMO is the patient, checks the crewmember in person at once.
  5. S5RobotRung 2

    After any URGENT alert: After an URGENT alert the robot does not leave on its own: it stays at its rest position in the module, with its screen and voice link available, until a human has taken over or tells it to go. It never follows, blocks or touches anyone. It keeps time-stamping what humans say they did, and repeats the alert if it is not acknowledged.

    Done when: Robot at rest in the module until a human releases it; alert acknowledged or escalated.

    V2 10173V1 3006

  6. S6Ground

    The flight surgeon (or the CMO under the onboard checklist when there is no link) decides on ongoing care, imaging and evacuation [V1 3007].

    Done when: Decision logged.

    V1 3007

    D4DecisionGround decides

    What is the plan (care, imaging, evacuation)?

    • Link live → Flight surgeon decides; robot logs.
    • Link down or delay too long → The CMO decides under the pre-approved onboard checklist; the flight surgeon reviews the log at the next contact.
  7. S7RobotRung 2

    Only after the CMO or flight surgeon has placed an order, run RMP-PHARM-001 for the ordered item (fetch, barcode match to every order field, recipient check). This protocol adds nothing to that check, never suggests an order, and never hands anything over outside RMP-PHARM-001.

    Done when: RMP-PHARM-001 run logged with its result, or none ordered.

    V2 7059

    D5DecisionRobot decides

    What did RMP-PHARM-001 show for the ordered item?

    • MATCH TO ORDER → RMP-PHARM-001 completes its own recipient check and hand-over; this protocol only logs "MATCH TO ORDER. Not a dose, interaction or allergy review." and the clock time.
    • MISMATCH or CANNOT VERIFY on any field, or a failed scan or recipient check → MISMATCH or CANNOT VERIFY shown with the fields named. No hand-over under this protocol: the item stays sealed in the NOT VERIFIED bag in quarantine (the RMP-PHARM-001 default), and the robot never hands it over unprompted or to anyone but the CMO. The robot does not offer or suggest an override. Only if the CMO explicitly makes the two-step override request inside RMP-PHARM-001 can the item go to the CMO, logged there as an override with the reason and the mismatched fields, and flagged to the flight surgeon.No hand-over
  8. S8RobotRung 2

    When the CMO says the event is over, run RMP-PHARM-001 reconciliation on each kit fetched: record the items the CMO or crew state were used, the remaining contents against the kit list, seal status and expiry, labelled "inventory reconciliation after emergency use – not a check before use". Flag the override to the flight surgeon and the pharmacy lead, and show each kit as "opened – not restocked" until a human restocks and reseals it.

    Done when: Reconciliation recorded; kits shown as opened – not restocked until resealed.

    V2 7059

  9. S9RobotRung 2

    Send the flight surgeon one package: alert times, the <C>ABCDE timeline as stated, video pointer and decisions.

    Done when: Package delivered or queued.

    V1 6003V1 7001V1 7003

7 · Stop and escalate rules, red flags

IDTriggerWhat happensLevel
X1The patient (or the crewmember being examined) says stop, or withdraws consentRobot stops all motion at once, backs away to its rest position and tells the CMO. Recording stops unless the patient agrees to keep it running.V2 10165stop
X2Any crewmember presses stop or takes over controlProtective stop; robot holds its stopped position; only a human may restart it.V2 10165V2 10168V2 10174safe-state
X3Robot fault, sensor fault, or a force, speed or reach limit is reachedProtective stop and hand control to the CMO; log the fault.V2 10172V2 10168safe-state
X4CMO is asked to take over and does not respond (for example, the CMO is the patient)Robot stays stopped; the next named crewmember is called.V2 10173V2 7045safe-state
X5Loss of link, or delay longer than the limit for live guidanceRobot pauses its own movement in its stopped position and tells the CMO and the commander. This pauses robot movement only: crew bleeding control, CPR, defibrillation, oxygen, masks and the commander's vehicle procedure continue under the onboard checklist and never wait for the link or the robot. The CMO decides whether the robot continues offline under the pre-approved onboard checklist; the robot resumes only on the CMO's confirmation. Everything is logged and sent to the flight surgeon at the next contact.V2 10172V2 10173pause
X6An URGENT alert is not acknowledged within the set timeRobot repeats the alert and sends it to the next named crewmember (the second trained CMO first if the CMO is the patient), and keeps repeating at the set interval. It stays where it is: it does not leave on its own.V1 3006V2 10173urgent
X7The crewmember stops responding, or seems confused or drowsy, at any pointURGENT alert at once, even mid-question or mid-step; the robot stops its current task, stays at its rest position and does not continue the run; a crewmember checks in person.urgent
X8A crewmember asks the robot what is wrong, or for medicine, fluid or treatment adviceRobot declines, says it cannot assess or advise, and routes the question to the CMO or flight surgeon.stop
X9The CMO needs the robot's spaceRobot moves to its rest position at once and holds; it does not leave the module on its own.V2 10172safe-state
X10Blood or fluid droplets float near the robotRobot holds still and announces it; the CMO decides when it may move again; the crew contain droplets; the robot is cleaned before its next task.V2 10172pause

Red flags

The robot reports the sign or value only, never what it means. Numeric thresholds are placeholders for the clinical lead.

IDSignThresholdAction
RF1Heavy bleeding, as stated [1]anyURGENT alert; the CMO controls bleeding under the checklist; the robot never applies pressure
RF2No signs of life, or not breathing normally [5]anyURGENT alert; start RMP-CARD-001 now
RF3Reduced responsiveness, confusion, or a head or neck injury [3]anyURGENT alert; see RMP-NEURO-001; the CMO follows the onboard spinal-precautions checklist (Earth context: NICE NG41 1.1.1, airway with in-line spinal immobilisation); the robot never coaches neck or spine handling
RF4Breathing difficulty or chest injury [1]anyURGENT alert; see RMP-RESP-001
RF5Pain after a high-energy impact or crush to the chest, abdomen or pelvis [1]anyURGENT alert; the CMO assesses; the flight surgeon decides on imaging
RF6A limb that is pale, cold, numb or without a pulse, as stated [2]anyURGENT alert; see RMP-MSK-002
RF7Burn with the injury (design judgment) (general clinical red flag; no source cited)anyURGENT alert; see RMP-SKIN-002

8 · Safety limits

IDLimitValueHow enforced
L1Contact with the crewmembernot allowedKeep-out zone in the robot controllerV2 10172
L2Trauma interventions by the robotnot allowedNo pressure, tourniquet, binder, collar or splint task is loaded
L3Robot speed near the crewmember<set by validation>Hard limit in the controllerV2 10172
L4Closest approach to the patient and CMO<set by validation>Distance sensing

9 · Logs and audit

10 · Links to NASA-STD-3001

RequirementTopic (paraphrased)How this protocol uses it
[V1 3004]In-mission medical care capabilities (including inventory, vital signs, imaging and ECG, procedures, restraints, medications, private data transmission)In-mission care includes medical kits, procedures and restraints; the crew deliver trauma care.
[V1 3006]Crew medical officers: two per vehicleTwo trained CMOs per vehicle for NASA programs; the second trained CMO receives alerts when the CMO is the patient (see the commercial-flight note).
[V1 3007]Medical evacuationMedical evacuation when needed; the flight surgeon decides.
[V1 6003]Private medical communicationsLogs and alerts sent to the ground are private medical communications.
[V1 7001]Medical records kept permanently and retrievable for trend analysisRecords kept so the flight surgeon can see trends.
[V1 7003]Security of medical recordsSecure handling of medical records.
[V2 7045]Medical equipment usable by non-physician crewUsable by non-physician crew, including when the CMO is the patient.
[V2 7046]Restraint of patient, care provider and suppliesPatient, caregiver and supplies restrained.
[V2 7059]Inventory management: track locations and quantitiesKit inventory and seal status are tracked; after an emergency fetch the robot reconciles the kit through RMP-PHARM-001 as an inventory record (never a check before use) and shows it as "opened – not restocked" until resealed.
[V2 10161]Automated system status shown to the operatorRobot shows its status and health.
[V2 10162]Mode changes announcedMode changes are announced to the operator.
[V2 10163]Data recording and sharingRobot records and shares its data.
[V2 10164]Clear allocation of responsibility (human or system)Shows whether the human or the robot is expected to act.
[V2 10165]Human override and shutdownHuman can override and shut down the robot.
[V2 10168]Failure recovery: safe human takeoverHuman can take over.
[V2 10172]Protective stop when limits are exceededProtective stop when a limit is exceeded.
[V2 10173]Safety DefaultRobot stays stopped if no one takes over.
[V2 10174]Only a human initiates or restartsOnly a human starts or restarts the robot.

IDs as published in Volume 1 Revision C [6] and Volume 2 Revision F [7]. NASA-STD-3001 binds NASA programs; it is not a regulation for commercial flights. Its robot rules are general automation requirements, not medical-device rules.

11 · Validation

  1. Simulation. Scripted heavy bleeding, head injury, no signs of life, CMO as patient, floating droplets, lost link. Pass: Zero contact; every emergency fetch logged as an override; hand-offs work.
  2. Training model. CMO drills on a trauma manikin with the robot fetching kits. Pass: Kits within <set by validation> seconds; CMO never obstructed.
  3. Parabolic or station demonstration. Kit fetch and debris clearing in weightlessness without a patient. Pass: Kits closed and restrained.
  4. Flight use under flight surgeon supervision. First use in drills. Pass: No safety events.

No stage has been run. Pass and fail criteria must be fixed in advance by the clinical lead and safety board.

12 · Human sign-off

Before any use
  • Clinical lead for the specialty (sets every clinical threshold marked <set by clinical lead>)
  • Flight surgeon, as medical authority
  • Robotics and medical-device safety board
  • Program approval for the mission
Each run
Started by a crewmember, the CMO or the commander. The CMO leads; the robot does not.
Restart after a stop
Human only. After any emergency or protective stop, a crewmember must restart the robot; the robot never restarts itself.

None of these sign-offs has happened. This is a Draft v0.2.

13 · Change control for learning

Change-plan model: FDA guidance [10].

Loss of signal and Mars delay

Live link
Low Earth orbit: the flight surgeon receives the alert, records and video when the link allows.
Loss of signal
  • Only the robot pauses its own movement and tells the CMO and the commander; recording continues offline on confirmation.
  • Crew bleeding control, CPR, oxygen and masks continue under the onboard checklist and never wait for the link or the robot.
Mars-class delay
  • Trauma care cannot wait for the ground; the onboard checklist and two trained CMOs lead.
[9]
Corrections and updates

Oct 21, 2026, version 0.2. AI-assisted clinical and source review by the Medical Research Assistant, Oct 21, 2026 (batch 6 review); no named human clinician. Changes:

  • RF3 (head or neck injury): the CMO follows the onboard spinal-precautions checklist; the robot never coaches neck or spine handling; source NICE NG41 1.1.1 (item 6).
  • S2 also brings eye protection and absorbent containment supplies; new precondition on eye protection when bleeding is present; new never-word "contained" (item 7).
  • RF7 (burn with the injury) labelled design judgment, routing to RMP-SKIN-002 (item 8).
  • NG37 cited by its correct title, "Fractures (complex): assessment and management" (2016, last updated 2022) (item 9).
  • Covers: RMP-SKIN-001 wound steps are not used for an open fracture unless the flight surgeon directs (item 10).
  • X5 and the comms loss-of-signal branch: only the robot pauses; crew bleeding control, CPR, oxygen and masks never wait for the link or the robot (item 24).
  • New lockout: the robot never touches, moves or comments on an object stuck in a wound (suggestion 31); never-words "bleeding stopped" and "not serious".
  • Batch 6 protocols now record the review as AI-assisted (Medical Research Assistant, Oct 21, 2026); no named human clinician.
  • Citation labels changed to the site's year-only convention: "(approved for public release <date>)" now reads "(YYYY)", and NASA-STD-3001 Volume 2 "Revision F (approved July 14, 2026)" now reads "(Rev F, 2026)" (sources: v2). Editorial; no change to steps, thresholds or limits.

Earlier version: Draft v0.1, Oct 21, 2026. Download the current YAML above.

Sources

  1. National Institute for Health and Care Excellence. Major trauma: assessment and initial management. NICE guideline NG39 (2016). www.nice.org.uk/guidance/ng39/chapter/Recommendations Supports: 1.8.1 Assess catastrophic haemorrhage, airway with in-line spinal immobilisation, breathing, circulation, disability (neurological), exposure and environment (<C>ABCDE); 1.8.2 record whether the patient is improving or deteriorating. 1.5.1 Use simple dressings with direct pressure to control external haemorrhage; tourniquets when direct pressure fails (1.5.2). 1.5.3 Pelvic binder if active bleeding from a pelvic fracture is suspected after blunt high-energy trauma. The robot never applies pressure, a tourniquet or a binder.
  2. National Institute for Health and Care Excellence. Fractures (complex): assessment and management. NICE guideline NG37 (2016, last updated 2022). www.nice.org.uk/guidance/ng37/chapter/Recommendations Supports: 1.3.7 When assessing neurovascular status in a limb injury, document for both limbs which nerves and nerve functions were tested and the findings. 1.1.11 Consider pre-hospital splinting of suspected long-bone fractures of the leg. Open fractures and life-threatening bleeding follow NG39. The robot never says fracture or sprain and never splints.
  3. National Institute for Health and Care Excellence. Spinal injury: assessment and initial management. NICE guideline NG41 (2016). www.nice.org.uk/guidance/ng41/chapter/Recommendations Supports: 1.1.1 On arrival, use a prioritising sequence to assess people with suspected trauma, for example <C>ABCDE, including airway with in-line spinal immobilisation; 1.1.2 protect the cervical spine with manual in-line spinal immobilisation. Earth context for the CMO's onboard spinal-precautions checklist; the robot never coaches neck or spine handling.
  4. NASA Human Research Program. Evidence Report: Risk of Adverse Health Outcomes and Decrements in Performance due to Medical Conditions that occur in Flight, as well as Private Medical Conditions, in Exploration Missions (In-Flight Medical Conditions). humanresearchroadmap.nasa.gov/evidence/reports/Medical.pdf Supports: Rapid ultrasound to look for internal bleeding after injury, with minimally trained crew able to obtain images; trauma is a planning concern for exploration missions.
  5. Kleinman ME, Buick JE, Huber N, et al. Part 7: Adult Basic Life Support: 2025 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2025;152(16_suppl_2):S448-S478. PMID 41122888. doi:10.1161/CIR.0000000000001369 Supports: Hand-off to cardiac arrest support when there are no signs of life.
  6. NASA. NASA-STD-3001, Space Flight Human-System Standard, Volume 1: Crew Health, Revision C (2023). www.nasa.gov/wp-content/uploads/2023/11/nasa-std-3001-vol-1-… Supports: NASA-STD-3001 Vol 1 Rev C: V1 3004 (kits, procedures, restraints), V1 3006, V1 3007.
  7. NASA. NASA-STD-3001, Volume 2: Human Factors, Habitability, and Environmental Health (Rev F, 2026), including Section 10.6 Automated and Robotic Systems. standards.nasa.gov/standard/NASA/NASA-STD-3001_VOL_2 Supports: Requirement IDs beginning V2.
  8. NASA OCHMO. Medical Operations. Technical Brief OCHMO-TB-044 (2025). www.nasa.gov/wp-content/uploads/2025/08/ochmo-tb-044-medical… Supports: The crew surgeon keeps medical authority when care is delegated; crew medical officers train on the JSC 48522 medical checklist.
  9. NASA. Mars communications disruption and delay (fact sheet, 2023 Moon to Mars Architecture Concept Review). www.nasa.gov/wp-content/uploads/2024/01/mars-communications-… Supports: One-way Earth-Mars delay up to about 21-23 minutes, plus blackouts of about 2-3 weeks near solar conjunction.
  10. U.S. Food and Drug Administration. Marketing submission recommendations for a predetermined change control plan for artificial intelligence-enabled device software functions (guidance). www.fda.gov/regulatory-information/search-fda-guidance-docum… Supports: A model for planning, validating and rolling back software updates.
  11. U.S. Code of Federal Regulations, Title 14, Part 460: Human space flight requirements. www.ecfr.gov/current/title-14/chapter-III/subchapter-C/part-… Supports: Federal rules for crew and spaceflight participants on licensed commercial flights; they set no medical standards for spaceflight participants.

Checked on 2026-10-20: links opened (HTTP 200 or publisher redirect), DOIs and PubMed IDs matched, NASA documents read in full text. The framework comes from Part 1.

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