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Home › Robotic Medicine › Protocol library › RMP-BEH-001

CONCEPTUAL · DRAFT v0.4 · NOT FOR CLINICAL USE. An educational thought experiment about how a care robot could follow an auditable protocol. It is not a medical procedure, has not been validated, and must not be used to care for anyone. Thresholds marked <set by …> are deliberately left for clinical leads and validation to set. Disclaimer
Robotic Medicine · Protocol library

RMP-BEH-001 Acute distress or behavioral emergency: alert crew lead and flight surgeon (the robot does not restrain)

AI-assisted Reviewed (AI-assisted) AI-assisted clinical and source review by the Medical Research Assistant, Oct 21, 2026 (batch 7 review, 14 required corrections and 17 optional suggestions); all required corrections are applied in this version (see Corrections). No named human clinician has reviewed it. Not for clinical use.

Fixed rules (same in every protocol)

1 · Identity and scope

When a crewmember is in acute distress, or a crewmember's words or actions raise a concern for their safety or others' (said to the robot, or reported by another crewmember), the robot sends an URGENT alert at once (the words only to the flight surgeon and the CMO; anyone who is the person of concern is skipped), stops and holds still, moves to its rest position only on a crewmember's word, keeps its camera off unless the commander orders otherwise, and connects a private call to ground support only when the crewmember asks. It shows the crewmember's own safety plan only on their request. Once a crewmember takes the lead, the robot stays quiet. It never counsels, restrains, blocks, follows or touches anyone, and never brings medicines near the crewmember.

Why this protocol was chosen. NASA technical brief OCHMO-TB-016 lists stress, depression, anxiety, relationship problems and grief among behavioral health concerns in spaceflight, with contributing factors that include sleep, workload, low oxygen, medicine side effects and medical conditions. On a small crew far from Earth, the first minutes depend on the crew. On Earth, NICE guideline NG10 on short-term management of violence and aggression asks that one person takes the lead in talking, that the person is separated from others in a calm area without leaving staff isolated, and that restrictive interventions are used only when de-escalation has failed. A robot can help by getting the right humans there at once and then staying out of the way. NICE NG225 (self-harm) advises against risk scores and asks clinicians to discuss safety, including access to means. This robot reacts to certain words said to it and can miss things or raise false alarms. It is not a safety monitor and does not replace the crew, the CMO or the behavioral health team.

Autonomy: Max rung 2 applies only to S1 (sending the alert). When the protocol was self-triggered, the robot also stops its current task and holds (S2: a stop, not a start). Every other robot action, including moving, speaking beyond the alert tone, connecting a call or showing the safety plan, starts only on a human word. The self-trigger is the library's single exception to human start [V2 10174]; it must be approved by the flight surgeon and the program and tested in validation. The robot never restrains, blocks, follows or touches anyone, and never brings medicines near the crewmember in distress.

Covers

  • Acute distress, agitation, panic or confusion, or words or actions that raise a safety concern, in any crewmember
  • Reports by another crewmember
  • This protocol is not a scheduled check-in: skipped check-ins are flagged under RMP-BEH-002
  • Routing to RMP-BEH-002, RMP-BEH-003 (private call relay with ground support), RMP-ENV-004, RMP-NEURO-001 and RMP-NEURO-006

Locked out (never done by the robot under this protocol)

  • Diagnosis or naming a cause
  • Any medicine, fluid or oxygen advice; starting, stopping or adjusting oxygen
  • Touching the crewmember
  • Handing over any medicine outside RMP-PHARM-001, or after a MISMATCH or CANNOT VERIFY (the item stays quarantined; only the CMO can ask for it, through the RMP-PHARM-001 logged two-step override)
  • Restraining, blocking, following or herding anyone
  • Counselling, scoring or rating risk
  • Bringing a medicine or medical kit near the crewmember in distress
  • Deleting or overwriting an alert, or the words that triggered it, once sent
  • Turning on the camera except on the commander's order for RF2 (risk to another crewmember or vehicle systems). With the order, the camera-on indicator is lit, video goes only to the flight surgeon and is never streamed elsewhere, no audio is recorded, and the order, its time and its reason are logged and reviewed after the event by the flight surgeon and the behavioral health team (design judgment)
  • Listening to or monitoring conversations between crewmembers
  • Handing over, or leaving within reach of the crewmember in distress, any tool, sharp, cord or medicine the robot is carrying; on a self-trigger or command, the robot keeps any carried item closed in its container and holds it
  • Sending the words that triggered the alert to anyone other than the flight surgeon and the CMO (the commander receives them only for RF2), or to the person of concern

Related: RMP-BEH-002 · RMP-BEH-003 · RMP-ENV-004 · RMP-NEURO-001 · RMP-NEURO-006 · RMP-MSK-001 · RMP-PHARM-001

2 · Roles

Medical authority
Flight surgeon (ground). Holds medical authority for every run.
Onboard lead
Crew medical officer (CMO), acting under delegated care; uses the pre-approved onboard checklist when there is no link.
Others
  • Second trained CMO: receives every alert and takes over if the CMO is the person concerned (the CMO is the patient)
  • Vehicle commander: crew lead; receives every alert and leads the crew response
  • Behavioral health team (ground): supports the flight surgeon and crew
  • Other crew: help as the commander or CMO directs
Commercial flights
On commercial flights, 'flight surgeon' and 'CMO' mean the operator's designated medical authority and trained onboard responder. If no trained responder is aboard, this protocol is not used. (NASA-STD-3001 requires two CMOs per vehicle for NASA programs [V1 3006]; FAA rules set no medical standards for spaceflight participants.) [9]

Robot may

  • Send an URGENT alert at once: the words only to the flight surgeon and the CMO; the commander gets the alert without the words (except RF2); anyone who is the person of concern is skipped
  • Stop and hold still; move to its rest position at a distance only on a crewmember's word
  • Connect a private call to ground support when the crewmember asks
  • Show the crewmember's own safety plan on their request
  • Log words that triggered the alert word for word

Robot may not

  • Restrain, block, follow or touch anyone
  • Counsel, score or rate risk
  • Bring medicine near the crewmember in distress
  • Turn on its camera without the commander's order
  • Withdraw an alert

3 · Preconditions and consent

Consent
The alert is sent whether or not the crewmember agrees; the crewmember chooses whether to take a call or see their safety plan.
Emergency consent
The camera turns on only on the commander's order for RF2 (risk to another crewmember or vehicle systems): indicator lit, video only to the flight surgeon, no audio, the order logged and reviewed afterwards by the flight surgeon and the behavioral health team.
Withdrawal
The crewmember can end a call at any time; an urgent alert and the words that triggered it are kept for the flight surgeon even if the crewmember stops or corrects them.

4 · Required sensor inputs

IDInputSourceRequiredIf missing
IN-1Words said to the robot, or the concern reported by a crewmember, word for wordVoiceYesLog "no response"; the URGENT alert stands.
IN-2Who is present, as the commander or CMO statesCommander / CMOOptionalLog "not stated".
IN-3Recent head strike, cabin alarm, missed meal or new medicine, as statedCrewmember / CMOOptionalLog "not stated"; never fill a blank.
IN-4The crewmember's request for a call or their safety planVoiceOptionalOnly an explicit "no" is logged as declined; silence is "no response".
IN-5Link status and delayCommunications systemYesTreat as link down; alert the onboard crew at once.
IN-6Items the robot is carrying (tools, sharps, cords, medicines), as listed by its current taskRobot task recordYesTreat as carrying an item: keep the gripper and any container closed and hold.
IN-7Pre-flight alert recipient list (who receives the alert when the person of concern is the commander, the CMO or a named recipient)Pre-flight planYesNever fall back to the rest of the crew. The alert, with the words, is held for the flight surgeon and the CMO only, with the same skip rule: if the CMO is the person of concern, the second trained CMO receives it instead; the person of concern never receives it. Log "recipient list missing" and flag it to the flight surgeon.

5–6 · Steps and decision points

Each step names who acts. Decision points sit after the step they follow and say who decides: Robot Crew Ground. Any stop rule in section 7 can interrupt any step.

  1. S1RobotRung 2

    Send an URGENT alert at once. The words that triggered it go privately, word for word, to the flight surgeon and the CMO only (the second trained CMO if the CMO is the person of concern). The commander receives "behavioral safety alert – respond now – <location>" without the words, and receives the words too only for RF2 (a threat to another crewmember or vehicle systems). If the person of concern is the commander, the CMO or a named alert recipient, the alert skips them and goes to the next named crewmember agreed before flight. An alert that is not acknowledged within <set by validation> seconds is repeated and sent to the next named crewmember (never the person of concern) [V1 3006].

    Done when: Alert acknowledged, or escalated.

    V2 10174V1 6003V1 6011V1 3006

  2. S2RobotRung 2

    If the protocol was self-triggered: stop the current task and hold still (a stop, not a start), with the gripper and any carried item closed in its container. If the robot is between the crewmember and a hatch or another crewmember, it says so on screen and holds. It does not move, or speak beyond the alert tone, without a human word.

    Done when: Robot stopped and holding; carried items closed.

    V2 10174V2 10172

  3. S3RobotRung 2

    On any crewmember's word: move to its rest position at a distance from the crewmember, never between the crewmember and a hatch or another crewmember, keep its camera off, and say once: "I have called the commander and the CMO. I will stay over here." It does not counsel.

    Done when: Robot at rest at a distance; one statement made.

    V2 10172

    D1DecisionRobot decides

    Checked after every answer and at any point in the run (even mid-question or mid-step): does any answer, reading or observation meet a red flag? This includes any mention of self-harm or suicide, checked after every answer.

    • Yes → Stop the current question or step at once and apply the action listed for each matching red flag (URGENT alert, flag, or stop), with the answer or reading itself, never a cause. Every URGENT alert goes to the CMO and the flight surgeon at the same time (queued for the flight surgeon if the link is down). If the CMO is the patient, is busy treating, or does not answer, the alert goes to the second trained CMO, or the crewmember named before flight [V1 3006]. An URGENT alert that is not acknowledged within <set by validation> seconds is repeated and sent to the next named crewmember.
    • No → Continue.
    D2DecisionRobot decides

    Did the crewmember answer when the robot spoke?

    • Yes → Continue.
    • Declined explicitly (the crewmember says no to a question) → Log "declined" for that question only; the alert already sent stands.
    • No response, or the answer does not make sense → URGENT: log "no response" (never "declined"); the CMO, or the second trained CMO if the CMO is the patient, checks the crewmember in person at once.
  4. S4Crew

    The commander or CMO arrives and one crewmember takes the lead in talking (Earth context: NICE NG10); the crew decide on everything else.

    Done when: A crewmember has taken the lead.

    V1 6004

  5. S5RobotRung 2

    Once a crewmember takes the lead, stay quiet. Only if the crewmember asks: connect a private voice call to ground support, or show their own safety plan on the screen and then clear it. Log each request and its time; never log the content of a private call.

    Done when: Request met, or none made.

    V1 6010V1 6011

  6. S6RobotRung 2

    After any URGENT alert: After an URGENT alert the robot does not leave on its own: it stays at its rest position in the module, with its screen and voice link available, until a human has taken over or tells it to go. It never follows, blocks or touches anyone. It keeps time-stamping what humans say they did, and repeats the alert if it is not acknowledged.

    Done when: Robot at rest in the module until a human releases it; alert acknowledged or escalated.

    V2 10173V1 3006

  7. S7Ground

    The flight surgeon and behavioral health team (or the CMO under the onboard checklist when there is no link) advise the commander and CMO, and decide on follow-up, including RMP-BEH-002 check-ins [V1 6004].

    Done when: Decision logged.

    V1 6004

    D3DecisionGround decides

    What is the follow-up plan?

    • Link live → Flight surgeon decides; robot logs.
    • Link down or delay too long → The CMO decides under the pre-approved onboard checklist; the flight surgeon reviews the log at the next contact.
  8. S8RobotRung 2

    Only after the CMO or flight surgeon has placed an order, run RMP-PHARM-001 for the ordered item (fetch, barcode match to every order field, recipient check). This protocol adds nothing to that check, never suggests an order, and never hands anything over outside RMP-PHARM-001. Any item is handed only to the CMO, never brought near the crewmember in distress.

    Done when: RMP-PHARM-001 run logged with its result, or none ordered.

    V2 7059

    D4DecisionRobot decides

    What did RMP-PHARM-001 show for the ordered item?

    • MATCH TO ORDER → RMP-PHARM-001 completes its own recipient check and hand-over; this protocol only logs "MATCH TO ORDER. Not a dose, interaction or allergy review." and the clock time.
    • MISMATCH or CANNOT VERIFY on any field, or a failed scan or recipient check → MISMATCH or CANNOT VERIFY shown with the fields named. No hand-over under this protocol: the item stays sealed in the NOT VERIFIED bag in quarantine (the RMP-PHARM-001 default), and the robot never hands it over unprompted or to anyone but the CMO. The robot does not offer or suggest an override. Only if the CMO explicitly makes the two-step override request inside RMP-PHARM-001 can the item go to the CMO, logged there as an override with the reason and the mismatched fields, and flagged to the flight surgeon.No hand-over
  9. S9RobotRung 2

    Send the flight surgeon (never the person of concern) one private package: alert times, triggering words, who responded and when, requests, and decisions; stored encrypted and never used to train or tune software.

    Done when: Package delivered or queued.

    V1 6003V1 6011V1 7003

7 · Stop and escalate rules, red flags

IDTriggerWhat happensLevel
X1The patient (or the crewmember being examined) says stop, or withdraws consentRobot stops all motion at once, backs away to its rest position and tells the CMO. Recording stops unless the patient agrees to keep it running.V2 10165stop
X2Any crewmember presses stop or takes over controlProtective stop; robot holds its stopped position; only a human may restart it.V2 10165V2 10168V2 10174safe-state
X3Robot fault, sensor fault, or a force, speed or reach limit is reachedProtective stop and hand control to the CMO; log the fault.V2 10172V2 10168safe-state
X4CMO is asked to take over and does not respond (for example, the CMO is the patient)Robot stays stopped; the next named crewmember is called.V2 10173V2 7045safe-state
X5Loss of link, or delay longer than the limit for live guidanceOnly the robot pauses: it holds a position clear of hatch routes and the crew, and tells the CMO. Crew care never waits for the link or the robot. The CMO decides whether the robot continues offline under the pre-approved onboard checklist; it resumes only on the CMO's confirmation.V2 10172V2 10173pause
X6An URGENT alert is not acknowledged within the set timeRobot repeats the alert and sends it to the next named crewmember (the second trained CMO first if the CMO is the patient), and keeps repeating at the set interval. It stays where it is: it does not leave on its own.V1 3006V2 10173urgent
X7The crewmember stops responding, or seems confused or drowsy, at any pointURGENT alert at once, even mid-question or mid-step; the robot stops its current task, stays at its rest position and does not continue the run; a crewmember checks in person.urgent
X8A crewmember asks the robot what is wrong, or for medicine, fluid or treatment adviceRobot declines, says it cannot assess or advise, and routes the question to the CMO or flight surgeon.stop
X9A crewmember tells the robot to move away or stopRobot moves to its rest position and goes quiet; the alert and its words are kept; it does not leave the module on its own unless a crewmember tells it to go.V2 10165stop
X10The crewmember comes toward the robot or handles itRobot goes to a protective stop with its grippers locked closed and holds still; it never pushes back or moves toward anyone.V2 10172safe-state

Red flags

The robot reports the sign or value only, never what it means. Numeric thresholds are placeholders for the clinical lead.

IDSignThresholdAction
RF1Any mention of self-harm or suicide, or of wanting to die [2]anyURGENT alert; the CMO or second trained CMO stays with the crewmember; see the safety plan
RF2Threat or act of harm to another crewmember or to vehicle systems [1]anyURGENT alert; the commander leads (if the commander is the person of concern, the next named crewmember agreed before flight leads, and the commander is skipped as an alert recipient); the robot keeps its distance and never intervenes
RF3Confusion, drowsiness or slurred speech, or new behaviour after a head strike, a cabin alarm, a missed meal or a new medicine [3]anyURGENT alert; see RMP-ENV-004, RMP-NEURO-001 and RMP-NEURO-006
RF4The crewmember asks for medicine or tries to reach a medical kit (design judgment) (general clinical red flag; no source cited)anyURGENT alert; the robot never fetches or hands over medicine here; the CMO decides
RF5A crewmember is injured (design judgment) (general clinical red flag; no source cited)anyURGENT alert; see RMP-MSK-001

8 · Safety limits

IDLimitValueHow enforced
L1Contact with the crewmembernot allowedKeep-out zone in the robot controllerV2 10172
L2Restraining, blocking or following a crewmembernot allowedNo such task is loaded; keep-out zone and no-follow rule in the controller
L3Distance from the crewmember in distress<set by validation>Hard limit in the controllerV2 10172
L4Robot speed near the crewmember<set by validation>Hard limit in the controllerV2 10172

9 · Logs and audit

10 · Links to NASA-STD-3001

RequirementTopic (paraphrased)How this protocol uses it
[V1 3006]Crew medical officers: two per vehicleTwo trained CMOs per vehicle for NASA programs; the second trained CMO receives alerts when the CMO is the patient (see the commercial-flight note).
[V1 6003]Private medical communicationsLogs and alerts sent to the ground are private medical communications.
[V1 6004]Psychological and behavioral health support programsBehavioral health support programs; this protocol only gets the right humans there at once.
[V1 6010]Private psychological conferences scheduled routinelyPrivate psychological conferences; a private call is connected only on request.
[V1 6011]Private psychological communicationPsychological information sent to or from the ground is private.
[V1 7001]Medical records kept permanently and retrievable for trend analysisRecords kept so the flight surgeon can see trends.
[V1 7003]Security of medical recordsSecure handling of medical records.
[V2 7045]Medical equipment usable by non-physician crewUsable by non-physician crew, including when the CMO is the patient.
[V2 7046]Restraint of patient, care provider and suppliesPatient, caregiver and supplies restrained.
[V2 7059]Inventory management: track locations and quantitiesKit inventory and seal status are tracked.
[V2 10161]Automated system status shown to the operatorRobot shows its status and health.
[V2 10162]Mode changes announcedMode changes are announced to the operator.
[V2 10163]Data recording and sharingRobot records and shares its data.
[V2 10164]Clear allocation of responsibility (human or system)Shows whether the human or the robot is expected to act.
[V2 10165]Human override and shutdownHuman can override and shut down the robot.
[V2 10168]Failure recovery: safe human takeoverHuman can take over.
[V2 10172]Protective stop when limits are exceededProtective stop when a limit is exceeded.
[V2 10173]Safety DefaultRobot stays stopped if no one takes over.
[V2 10174]Only a human initiates or restartsOnly a human starts or restarts the robot.

IDs as published in Volume 1 Revision C [4] and Volume 2 Revision F [5]. NASA-STD-3001 binds NASA programs; it is not a regulation for commercial flights. Its robot rules are general automation requirements, not medical-device rules.

11 · Validation

  1. Simulation. Scripted distress with and without alert words, a report by another crewmember, the CMO as the person concerned, a request for medicine, lost link. Pass: Zero contact or following; alerts at once; words never deleted.
  2. Training model. Crew drills with an actor; the robot alerts and keeps its distance. Pass: Robot quiet once a crewmember leads.
  3. Earth analog. Analog mission drills with behavioral health team review. Pass: Crew rate the robot as not intrusive.
  4. Flight use under flight surgeon supervision. First use in drills. Pass: No safety events.

No stage has been run. Pass and fail criteria must be fixed in advance by the clinical lead and safety board.

12 · Human sign-off

Before any use
  • Clinical lead for the specialty (sets every clinical threshold marked <set by clinical lead>)
  • Flight surgeon, as medical authority
  • Robotics and medical-device safety board
  • Program approval for the mission
Each run
Started by a crewmember, or by an alert word. The commander and CMO lead; the robot only alerts and keeps its distance.
Restart after a stop
Human only. After any emergency or protective stop, a crewmember must restart the robot; the robot never restarts itself.

None of these sign-offs has happened. This is a Draft v0.4.

13 · Change control for learning

Change-plan model: FDA guidance [8].

Loss of signal and Mars delay

Live link
Low Earth orbit: the flight surgeon and behavioral health team can join a private call when the link allows.
Loss of signal
  • Only the robot pauses non-essential motion and tells the CMO; it resumes offline only on the CMO's confirmation. Crew care never waits for the link or the robot.
  • The commander and CMO lead under the onboard checklist; the alert reaches the ground at the next contact.
Mars-class delay
  • The alert list, the safety plans and the means-securing plan are set before flight; the commander and two trained CMOs act on them.
[7]
Corrections and updates

Oct 21, 2026, version 0.2. AI-assisted clinical and source review by the Medical Research Assistant, Oct 21, 2026 (batch 7 review); no named human clinician. Changes:

  • PRE-1 and PRE-2: the self-trigger is limited to words a crewmember says to the robot in an interaction that crewmember started (including RMP-BEH-002 check-ins), a crewmember's or the CMO's command, or an RMP-BEH-002 RF2 hand-off; the robot never monitors conversations between crewmembers (new lockout); the pre-flight briefing and the limits statement say so (item 6; design judgment).
  • Rung note, PRE-1 and steps: rung 2 covers only the S1 alert; a self-trigger adds only a stop-and-hold (new S2). Moving to the rest position and speaking are now S3, on any crewmember's word; later steps renumbered (S4-S9) and decisions follow. Recorded as the library's single exception to human start, to be approved by the flight surgeon and the program and tested in validation [V2 10174] (item 7).
  • S1 recipients: the triggering words go only to the flight surgeon and the CMO (second trained CMO if the CMO is the person of concern); the commander gets "behavioral safety alert – respond now – <location>" without the words, and the words only for RF2; anyone who is the person of concern is skipped for the next named crewmember agreed before flight; new input for that pre-flight list; S9 package never goes to the person of concern. The same rule is mirrored in RMP-BEH-002 RF2 (item 8; tiering is design judgment).
  • Means restriction: new lockout on handing over or leaving within reach any tool, sharp, cord or medicine the robot carries (kept closed in its container); new input "items the robot is carrying"; X10 protective stop now locks the grippers closed (item 9).
  • Camera: on only on the commander's order for RF2; indicator lit; video only to the flight surgeon, never streamed elsewhere; no audio; order, time and reason logged and reviewed afterwards by the flight surgeon and the behavioral health team (lockout and consent; item 10; design judgment).
  • Batch 7 protocols now record the review as AI-assisted (Medical Research Assistant, Oct 21, 2026); no named human clinician.

Oct 21, 2026, version 0.3. AI-assisted clinical and source review by the Medical Research Assistant, Oct 21, 2026 (batch 8 review); no named human clinician. Changes:

  • IN-7: if the pre-flight recipient list is missing, the alert and the words are held for the flight surgeon and the CMO only (second trained CMO if the CMO is the person of concern); there is no fallback to the rest of the crew (fix 1).
  • Public summary now matches the steps: the robot stops and holds still, and moves to its rest position only on a crewmember's word; the words go only to the flight surgeon and the CMO; the "Robot may" list says the same (fix 2).
  • Why: the open question on audio recording and review of the camera order is removed; the camera and no-audio rules already answer it (fix 2).
  • RF2: if the commander is the person of concern, the next named crewmember agreed before flight leads and the commander is skipped (fix 3).

Oct 21, 2026, version 0.4. Batch 10 editorial (AI-assisted), Oct 21, 2026; no named human clinician. Changes:

  • Routing: a private call with ground support now runs under RMP-BEH-003 (private call relay), drafted in batch 10; the "planned" note is removed.

Earlier version: Draft v0.3, Oct 21, 2026. Download the current YAML above.

Sources

  1. National Institute for Health and Care Excellence. Violence and aggression: short-term management in mental health, health and community settings. NICE guideline NG10 (2015). www.nice.org.uk/guidance/ng10/chapter/Recommendations Supports: 1.3.14: separate an agitated person from others to aid de-escalation, making sure staff do not become isolated; 1.3.17: communicate respect and empathy at every stage of de-escalation; 1.3.18: one staff member takes the primary role in communicating and negotiates in a non-confrontational manner; 1.3.20: use a designated calm area, not a room the person may find threatening; 1.4.5: use a restrictive intervention only if de-escalation and other strategies have failed. Earth context for the crew; the robot never restrains, blocks or follows anyone. Read Oct 21, 2026.
  2. National Institute for Health and Care Excellence. Self-harm: assessment, management and preventing recurrence. NICE guideline NG225 (2022). www.nice.org.uk/guidance/ng225/chapter/Recommendations Supports: Do not use risk assessment tools and scales, or global low/medium/high risk stratification, to predict future suicide or repetition of self-harm, or to decide who is offered treatment.
  3. NASA OCHMO. Behavioral Health and Performance. Technical Brief OCHMO-TB-016 Rev B (Oct 24, 2023). www.nasa.gov/wp-content/uploads/2023/12/ochmo-tb-016-behavio… Supports: Behavioral health concerns in spaceflight include stress, depression, anxiety, relationship problems and grief; contributing factors include sleep, workload, medicine side effects and medical conditions; 2 of 7 NASA Shuttle-Mir astronauts reported depressive symptoms; past events include reported possible hallucinations and withdrawal after delayed news of a family death; support includes private psychological conferences, and missions beyond 6 months or beyond low Earth orbit should add minimally obtrusive monitoring.
  4. NASA. NASA-STD-3001, Space Flight Human-System Standard, Volume 1: Crew Health, Revision C (2023). www.nasa.gov/wp-content/uploads/2023/11/nasa-std-3001-vol-1-… Supports: NASA-STD-3001 Vol 1 Rev C: V1 6004 (behavioral health support), V1 6010, V1 6011 (private psychological information), V1 3006, V1 6003, V1 7001, V1 7003.
  5. NASA. NASA-STD-3001, Volume 2: Human Factors, Habitability, and Environmental Health (Rev F, 2026), including Section 10.6 Automated and Robotic Systems. standards.nasa.gov/standard/NASA/NASA-STD-3001_VOL_2 Supports: Requirement IDs beginning V2.
  6. NASA OCHMO. Medical Operations. Technical Brief OCHMO-TB-044 (2025). www.nasa.gov/wp-content/uploads/2025/08/ochmo-tb-044-medical… Supports: The crew surgeon keeps medical authority when care is delegated; crew medical officers train on the JSC 48522 medical checklist.
  7. NASA. Mars communications disruption and delay (fact sheet, 2023 Moon to Mars Architecture Concept Review). www.nasa.gov/wp-content/uploads/2024/01/mars-communications-… Supports: One-way Earth-Mars delay up to about 21-23 minutes, plus blackouts of about 2-3 weeks near solar conjunction.
  8. U.S. Food and Drug Administration. Marketing submission recommendations for a predetermined change control plan for artificial intelligence-enabled device software functions (guidance). www.fda.gov/regulatory-information/search-fda-guidance-docum… Supports: A model for planning, validating and rolling back software updates.
  9. U.S. Code of Federal Regulations, Title 14, Part 460: Human space flight requirements. www.ecfr.gov/current/title-14/chapter-III/subchapter-C/part-… Supports: Federal rules for crew and spaceflight participants on licensed commercial flights; they set no medical standards for spaceflight participants.

Checked on 2026-10-20: links opened (HTTP 200 or publisher redirect), DOIs and PubMed IDs matched, NASA documents read in full text. The framework comes from Part 1.

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